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Journal of Chemical Theory and Computation

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May 5, 2026, Volume 38, Issue 5, pp. 833–1050. Under a starlit sky, a mouse sits contentedly beside protein-rich cheese, its appetite quelled. The cosmos above tells the story—clouds sculpted into the arcuate nucleus cradle constellations forming the T-type calcium channel Cav3.1, while leucine-shaped shooting stars rain down upon them. This celestial tableau captures the discovery by Tsang et al. that leucine directly binds Cav3.1 in hypothalamic POMC neurons, lowering its activation threshold and triggering satiety, revealing a molecular sensor linking dietary protein to appetite suppression. ×

Cell Metabolism

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April 14, 2026, Volume 22, Issue 7, pp. 3127–3778. Artistic rendition of photon absorption by a photoacid, followed by excited-state proton transfer, nonadiabatic transition through a conical intersection, and ground-state relaxation. ×

Journal of Chemical Theory and Computation